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KMID : 0644120080210040017
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Journal of Oriental Gynecology
2008 Volume.21 No. 4 p.17 ~ p.35
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Anti-inflammatory Effects of Gagamsoyosan
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Kim Ju-Yeoun
Lee Soon-Yee
Cho Han-Baek
Kim Song-Baek
Choe Chang-Min
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Abstract
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Purpose: It is the purpose of this study to investigate the anti-inflammatory effects of water extract from Gagamsoyosan(GGSYS) on the peritoneal macrophage.
Methods: To evaluate anti-inflammatory effects of GGSYS. inflammatory cytokines were measured in lipopolysaccharide(LPS) -stimulated macrophages. Furthermore. the western blot has been done to look into the molecular mechanism.
Results: GGSYS did not have any cytotoxicity in the peritoneal macrophages and suppressed production of LPS-induced NO. tumor necrosis factor-alpha (TNF-α). interleukin(IL)-1β. IL-6. IL-12. GGSYS inhibited the activation of extracelluar signal-regulated kinase (ERK1/2). c-Jun N-terminal kinase(JNK), p38 kinase and the degradation of inhibitory kappa B-alpha(IκB-α) in the LPS-stimulated peritoneal macro phages. GGSYS inhibited LPS-induced endotoxin shock and the production of TNF-α, IL-lβ. IL-6 in serum from LPS-stimulated mice.
Conclusion: These results suggest that GGSYS may have the anti-inflammatory effect which can inhibit the production of NO and inflammatory cytokines. GGSYS is expected to protect against inflammatory diseases.
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KEYWORD
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Gagamsoyosan(GGSYS), herbal medicine, inflammatory cytokine, LPS, endotoxin shock
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